Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | TEK | Q02763 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 11/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 10/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067236 | 0.79 | ABL1 (0.52) | LCKKDRTEKKITDDR1 | |
| SCHEMBL22529514 | 0.77 | LCK (0.57) | LCKKDRTEKKITDDR1 | |
| SCHEMBL4062149 | 0.77 | CSF1R (0.46) | LCKKDRTEKKITDDR1 | |
| SCHEMBL4068674 | 0.75 | KDM4E (0.49) | LCKKDRTEKKITDDR1 | |
| SCHEMBL4063968 | 0.74 | CSF1R (0.62) | KITDDR1CSF1RABL1 | |
| SCHEMBL14616920 | 0.73 | HAO1 (0.50) | KITDDR1CSF1R | |
| SCHEMBL18247795 | 0.73 | KIT (0.45) | LCKKDRTEKKITDDR1 | |
| SCHEMBL29483761 | 0.73 | KIT (0.45) | LCKKDRTEKKITDDR1 | |
| SCHEMBL11298523 | 0.72 | ABL1 (0.64) | LCKKDRTEKKITDDR1 | |
| SCHEMBL29722360 | 0.72 | ABL1 (0.64) | LCKKDRTEKKITDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2023933-A2 | ACETYLENIC HETEROARYL COMPOUNDS | ARIAD PHARMACEUTICALS, INC. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007133560-A9 | ACETYLENIC HETEROARYL COMPOUNDS | ARIAD PHARMA INC (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2007133560-A2 | ACETYLENIC HETEROARYL COMPOUNDS | ARIAD PHARMACEUTICALS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |