Sugi Predict

Sugi Predict / Compounds / SCHEMBL11298523

SCHEMBL11298523

SCHEMBL11298523

Cc1ccc(C(=O)O)cc1C#Cc1cnc2ccccc2c1

nearest known ligand 0.64

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 1/20 0.64
▸ BCR P11274 1/20 0.64
▸ KDR P35968 4/20 0.62
▸ LCK P06239 3/20 0.62
▸ TEK Q02763 3/20 0.62
▸ MGAM O43451 1/20 0.52
▸ ALDH1A1 P00352 1/20 0.48
▸ KIT P10721 9/20 0.46
▸ DDR1 Q08345 7/20 0.46
▸ ACACB O00763 1/20 0.46
▸ KDM4E B2RXH2 1/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ MITF O75030 1/20 0.43
▸ XBP1 P17861 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ PAX8 Q06710 1/20 0.43
▸ KLF5 Q13887 1/20 0.43
▸ DDR2 Q16832 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29722360 1.00 ABL1 (0.64) ABL1BCRKDRLCKTEK
SCHEMBL11297514 0.90 ABL1 (0.64) ABL1BCRKDRLCKTEK
SCHEMBL11297517 0.88 ABL1 (0.58) ABL1BCRKDRLCKTEK
SCHEMBL15363890 0.88 ABL1 (0.75) ABL1BCRKDRLCKTEK
SCHEMBL11298448 0.87 ABL1 (0.63) ABL1BCRKDRLCKTEK
SCHEMBL15364080 0.87 ABL1 (0.50) ABL1BCRKDRLCKTEK
SCHEMBL11297126 0.86 ABL1 (0.68) ABL1BCRKDRLCKTEK
SCHEMBL11298529 0.85 MGAM (0.52) ABL1BCRKDRLCKTEK
SCHEMBL11305247 0.85 PDGFRB (0.51) ABL1BCRKDRLCKTEK
SCHEMBL11306433 0.85 ABL1 (0.53) ABL1BCRKDRLCKTEK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11351123-B2 Amorphous dispersion of 4-methyl-3-quinolin-3-ylethynyl-benzoic acid n'-(2-chloro-6-methyl-benzoyl) hydrazide SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) 2022-06-07 — — US disclosed
US-11351123-B2 Amorphous dispersion of 4-methyl-3-quinolin-3-ylethynyl-benzoic acid n'-(2-chloro-6-methyl-benzoyl) hydrazide SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) 2022-06-07 — — US disclosed
US-20200085751-A1 NOVEL AMORPHOUS DISPERSION OF 4-METHYL-3-QUINOLIN-3-YLETHYNYL-BENZOIC ACID N'-(2-CHLORO-6-METHYL-BENZOYL) HYDRAZIDE SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) 2020-03-19 — — US disclosed
US-20200085751-A1 NOVEL AMORPHOUS DISPERSION OF 4-METHYL-3-QUINOLIN-3-YLETHYNYL-BENZOIC ACID N'-(2-CHLORO-6-METHYL-BENZOYL) HYDRAZIDE SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) 2020-03-19 — — US disclosed
EP-2665709-B1 DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS SUN PHARMA ADVANCED RES CO LTD (IN) 2016-12-07 — — EP disclosed
EP-2665709-B1 DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS SUN PHARMA ADVANCED RES CO LTD (IN) 2016-12-07 — — EP disclosed
US-9024021-B2 Diarylacetylene hydrazide containing tyrosine kinase inhibitors SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) 2015-05-05 — — US disclosed
US-9024021-B2 Diarylacetylene hydrazide containing tyrosine kinase inhibitors SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) 2015-05-05 — — US disclosed
US-9024021-B2 Diarylacetylene hydrazide containing tyrosine kinase inhibitors SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) 2015-05-05 — — US disclosed
CN-103502217-A Diarylacetylene hydrazide containing tyrosine kinase inhibitors SUN PHARMA ADVANCED RES CO LTD 2014-01-08 — — CN disclosed
EP-2665709-A1 DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS Sun Pharma Advanced Research Company Limited (IN) 2013-11-27 — — EP disclosed
US-20130296557-A1 DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) 2013-11-07 — — US disclosed
US-20130296557-A1 DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) 2013-11-07 — — US disclosed
US-20130296557-A1 DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) 2013-11-07 — — US disclosed
WO-2012098416-A1 DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) 2012-07-26 — — WO disclosed
WO-2012098416-A1 DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) 2012-07-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200085751-A1 NOVEL AMORPHOUS DISPERSION OF 4-METHYL-3-QUINOLIN-3-YLETHYNYL-BENZOIC ACID N'-(2-CHLORO-6-METHYL-BENZOYL) HYDRAZIDE ABCG2, ACMSD, CYP2D6 ABL1 1155/4885BCR 1370/4885KDR 3902/4885
US-20130296557-A1 DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS ABL1, LCK, JAK2 ABL1 1/4885BCR 130/4885KDR 277/4885
US-11351123-B2 Amorphous dispersion of 4-methyl-3-quinolin-3-ylethynyl-benzoic acid n'-(2-chloro-6-methyl-benzoyl) hydrazide ABCG2, ACMSD, CYP2D6 ABL1 962/4885BCR 1381/4885KDR 4011/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.