Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4252261 | 0.86 | CCNT1 (0.50) | STK4MTORSMG1JAK2 | |
| SCHEMBL4247112 | 0.85 | IKBKB (0.43) | SYKMTORSMG1JAK2 | |
| SCHEMBL13911407 | 0.84 | IKBKB (0.50) | PLK1PLK3PLK2SYKMAPT | |
| SCHEMBL13911365 | 0.84 | AXL (0.47) | ALDH1A1SMN1; SMN2LMNAMTORSMG1 | |
| SCHEMBL12231909 | 0.83 | ALDH1A1 (0.54) | PLK1PLK3PLK2SYKSTK4 | |
| SCHEMBL4247827 | 0.83 | KDM4E (0.40) | GAAMAPTMTORSMG1JAK2 | |
| SCHEMBL4251991 | 0.82 | NAMPT (0.40) | ALDH1A1SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL13911406 | 0.82 | IKBKB (0.41) | PLK1PLK3PLK2SYKALDH1A1 | |
| SCHEMBL24180552 | 0.82 | BRD4 (0.41) | PLK1PLK3PLK2SYKSTK4 | |
| SCHEMBL13911404 | 0.81 | IKBKB (0.41) | PLK1PLK3PLK2MAPTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101563336-A | Heterocyclic organic compounds for the treatment of in particular melanoma | NOVARTIS AG (CH) | 2009-10-21 | — | — | CN | disclosed |
| US-20090069360-A1 | Organic Compounds | CARAVATTI, GIORGIO (CH) | 2009-03-12 | — | — | US | disclosed |
| US-20090069360-A1 | Organic Compounds | CARAVATTI, GIORGIO (CH) | 2009-03-12 | — | — | US | disclosed |
| US-20090069360-A1 | Organic Compounds | CARAVATTI, GIORGIO (CH) | 2009-03-12 | — | — | US | disclosed |
| WO-2007109045-A1 | HETEROCYCLIC ORGANIC COMPOUNDS FOR THE TREATMENT OF IN PARTICULAR MELANOMA | NOVARTIS AG (CH) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069360-A1 | Organic Compounds | BRAF, MAP3K1, RAF1 | GRM4 3376/4885PLK1 246/4885PLK3 241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.