Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4247381 | 0.85 | EPHX2 (0.62) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4245870 | 0.85 | EPHX2 (0.65) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4245873 | 0.83 | EPHX2 (0.63) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4252890 | 0.82 | EPHX2 (0.64) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL14409476 | 0.81 | EPHX2 (0.64) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4253798 | 0.80 | EPHX2 (0.73) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4252882 | 0.80 | EPHX2 (0.67) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4245826 | 0.79 | EPHX2 (0.60) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL13702057 | 0.78 | EPHX2 (0.54) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL13702056 | 0.77 | EPHX2 (0.53) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | EPHX1, EPHX2, EPX | EPHX2 2/4885ALOX5 60/4885TBXAS1 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.