EPX — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL19359413	0.72	2/20
SCHEMBL22423839	0.72	2/20
SCHEMBL22423896	0.72	2/20
SCHEMBL19381399	0.62	2/20
SCHEMBL22406585	0.59	2/20
SCHEMBL19359408	0.59	2/20
SCHEMBL22406417	0.56	2/20
SCHEMBL22406473	0.56	2/20
SCHEMBL22423888	0.56	2/20
SCHEMBL22423899	0.56	2/20
SCHEMBL22406550	0.54	2/20
SCHEMBL22406553	0.54	2/20
SCHEMBL22423877	0.54	2/20
SCHEMBL22424121	0.54	2/20
SCHEMBL22406409	0.54	2/20
SCHEMBL22406482	0.54	2/20
SCHEMBL22406647	0.54	2/20
SCHEMBL22406682	0.53	2/20
SCHEMBL22423876	0.53	2/20
SCHEMBL22423914	0.53	2/20

Clinical trials — most relevant to EPX by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Dupilumab on Aspirin Intolerance	PHASE4	UNKNOWN
INvestigating COPD Outcomes, Genomics and Neutrophilic Inflammation With Tiotropium and Olodaterol	PHASE4	COMPLETED
Zemaira Eosinophilic Esophagitis Pilot Study	PHASE2	RECRUITING
IL-13 Blockade and Airway Autoimmunity in Asthma	nan	COMPLETED
Minimally Invasive Biomarker for Asthma Disease Severity	nan	COMPLETED
EDN and Eosinophilic Esophagitis	nan	RECRUITING
Esophageal String Test in Eosinophilic Esophagitis	nan	ACTIVE_NOT_RECRUITING
A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression	nan	RECRUITING
Airway Inflammation and Bronchial Hyperresponsiveness in Rhinitic Children With or Without Asthma	nan	COMPLETED
Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia	nan	RECRUITING
Eosinophilic Esophagitis: Towards Improved Management	nan	RECRUITING
Effects of Green Tea Extract (GTE) on Systemic Oxidative and Antioxidative Status in Chinese Patients With Stable Asthma	nan	COMPLETED
Effect of Mepolizumab on Severe Eosinophilic Asthma	nan	UNKNOWN
Identification of Autoantigens in EGPA and Severe Eosinophilic Asthma	nan	COMPLETED
Eosinophil β1 Integrin Activation as a Biomarker for Eosinophilic Esophagitis	nan	COMPLETED
Montelukast in the Treatment of Duodenal Eosinophilia	nan	COMPLETED
The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping	nan	ACTIVE_NOT_RECRUITING
Serum Esnophilic Cationic Protein Level as Diagnostic Marker in Cow Milk Protein Allergy Infants	nan	UNKNOWN
Cough Suppressive Therapy in Patients With Chronic Cough	nan	UNKNOWN
Non-coding RNAs Analysis of Eosinophil Subtypes in Asthma	nan	UNKNOWN
New Serological Markers for Eosinophilic Esophagitis	nan	UNKNOWN
Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis	nan	ACTIVE_NOT_RECRUITING
Nasal Nitric Oxide Levels in Eosinophilic Esophagitis (EoE)	nan	COMPLETED
Phenotyping Circulating and Lung Resident Eosinophils in Severe Asthma (P-CLESA)	nan	UNKNOWN
Sponge and Eosinophil Peroxidase (EPO) Staining	nan	COMPLETED
Mechanisms of Action of Acetaminophen	nan	COMPLETED
Metabolomics for Biomarker Discovery in Children With EoE	nan	COMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits	nan	COMPLETED
AsthMatic Inflammation and Neurocircuitry Activation (MINA)	nan	COMPLETED
The Study of Differences in Eosinophil Function and Subsets in Patients With Eosinophilic Pulmonary Diseases	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a EPX binder may also engage these)

Protein	Name	Similarity
P49290	—	0.991	P49290 →
MPO	Myeloperoxidase	0.984	landscape →
P11247	—	0.977	P11247 →
LPO	Lactoperoxidase	0.913	landscape →
A1KZ92	—	0.910	A1KZ92 →
Q8R481	—	0.909	Q8R481 →
A4IGL7	—	0.906	A4IGL7 →
A0A452E9Y6	—	0.904	A0A452E9Y6 →
DUOX2	Dual oxidase 2	0.903	landscape →
Q8CIY2	—	0.901	Q8CIY2 →
Q9ES45	—	0.900	Q9ES45 →
Q9MZF4	—	0.900	Q9MZF4 →
Q5SW46	—	0.900	Q5SW46 →
Q8HZK3	—	0.899	Q8HZK3 →
Q8HZK2	—	0.899	Q8HZK2 →
Q01603	—	0.898	Q01603 →
A2AQ92	—	0.896	A2AQ92 →
O97583	—	0.896	O97583 →
DUOX1	Dual oxidase 1	0.896	landscape →
Q9D2G9	—	0.895	Q9D2G9 →
P70669	—	0.895	P70669 →
Q9GZT5	—	0.893	Q9GZT5 →
Q9VQH2	—	0.892	Q9VQH2 →
Q96JK4	—	0.892	Q96JK4 →
O77564	—	0.892	O77564 →
P48615	—	0.892	P48615 →
G5E897	—	0.892	G5E897 →
P78562	—	0.891	P78562 →
O96014	—	0.891	O96014 →
Q08410	—	0.891	Q08410 →