Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 11/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2080378 | 0.86 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11CDK9 | |
| Sulfuric Acid SCHEMBL4067935 | 0.82 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11CDK9 | |
| SCHEMBL4076097 | 0.81 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4076100 | 0.81 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2078495 | 0.81 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11CDK9 | |
| SCHEMBL2079289 | 0.81 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11CDK9 | |
| SCHEMBL4071382 | 0.79 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4067939 | 0.77 | MAPK14 (0.60) | MAPK14MAP4K1 | |
| SCHEMBL2080269 | 0.77 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11CDK9 | |
| SCHEMBL2079373 | 0.77 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049537-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2009-04-22 | — | — | EP | claimed |
| WO-2008017461-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-02-14 | — | — | WO | claimed |