Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4971290 | 1.00 | REN (0.51) | RENHPGDSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL971028 | 0.89 | REN (0.51) | RENHPGDSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL971027 | 0.89 | REN (0.51) | RENHPGDSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2332892 | 0.88 | REN (0.49) | RENHPGDALDH1A1LMNA | |
| SCHEMBL2332896 | 0.88 | REN (0.49) | RENHPGDALDH1A1LMNA | |
| SCHEMBL2332899 | 0.88 | REN (0.49) | RENHPGDALDH1A1LMNA | |
| SCHEMBL4972630 | 0.86 | REN (0.45) | RENHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4974097 | 0.83 | REN (0.53) | REN | |
| SCHEMBL4978806 | 0.83 | REN (0.53) | REN | |
| SCHEMBL4974903 | 0.83 | REN (0.46) | RENHPGDSMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081927-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1966139-A1 | ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2008036216-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2007070201-A1 | ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |