SCHEMBL4246345

SCHEMBL4246345

NC(=O)c1ccc(OCc2ccccc2)cc1.O=C(O)N1CCC(Cc2ccccc2)CC1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 2/20 0.64
GAA P10253 1/20 0.59
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
POLB P06746 1/20 0.55
LTB4R Q15722 1/20 0.53
LTB4R2 Q9NPC1 1/20 0.53
ADAMTS5 Q9UNA0 1/20 0.51
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA7 P43166 1/20 0.50
CA9 Q16790 1/20 0.50
CA14 Q9ULX7 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
RAB9A P51151 1/20 0.49
NR4A1 P22736 1/20 0.49
NR4A2 P43354 1/20 0.49
NR4A3 Q92570 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4245174 0.94 PARP10 (0.60) PARP10GAAMEN1KMT2APOLB
SCHEMBL4239346 0.94 PARP10 (0.56) PARP10GAAMEN1KMT2APOLB
SCHEMBL4244744 0.91 PARP10 (0.53) PARP10GAAMEN1KMT2APOLB
SCHEMBL4251983 0.90 PARP10 (0.62) PARP10GAARAB9ANR4A1NR4A2
SCHEMBL27670250 0.89 PARP10 (0.61) PARP10RAB9ANR4A1NR4A2NR4A3
SCHEMBL4239619 0.87 GAA (0.65) GAAMEN1KMT2ACA12CA1
SCHEMBL4242851 0.85 PARP10 (0.51) PARP10GAAMEN1KMT2APOLB
SCHEMBL5165728 0.84 GAA (0.65) GAAMEN1KMT2ACA12CA1
SCHEMBL4768629 0.84 GAA (0.67) GAAMEN1KMT2APOLBCA12
SCHEMBL27689205 0.84 PARP10 (0.58) PARP10RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090170901-A1 Benzoyl Urea Derivatives RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2009-07-02 US disclosed
EP-1771429-A1 NEW BENZOYL UREA DERIVATIVES RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2007-04-11 EP disclosed
WO-2006010966-A1 NEW BENZOYL UREA DERIVATIVES Richter Gedeon Vegyészeti Gyár Rt. (HU) 2006-02-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090170901-A1 Benzoyl Urea Derivatives OPRM1, GRIN2C, GRIN3A PARP10 3694/4885GAA 3604/4885MEN1 4432/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.