SCHEMBL4247258

SCHEMBL4247258

CCCCCCOC(=O)c1cc(=O)c2cc(N)ccc2o1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.59
ALDH1A1 P00352 3/20 0.53
MAPT P10636 2/20 0.53
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53
AKR1B1 P15121 1/20 0.47
TSHR P16473 3/20 0.46
LMNA P02545 2/20 0.46
CYP3A4 P08684 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
PDE4D Q08499 1/20 0.46
KDM4E B2RXH2 1/20 0.45
POLB P06746 1/20 0.45
HSD17B10 Q99714 1/20 0.45
ALOX15 P16050 1/20 0.43
MAPK1 P28482 2/20 0.42
KMT2A Q03164 1/20 0.42
SRC P12931 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4254462 0.99 MAOB (0.60) MAOBALDH1A1MAPTNPC1RAB9A
SCHEMBL4258027 0.95 MAOB (0.62) MAOBALDH1A1MAPTNPC1RAB9A
SCHEMBL4254609 0.91 MAOB (0.59) MAOBALDH1A1MAPTNPC1RAB9A
SCHEMBL4258065 0.90 MAOB (0.72) MAOBALDH1A1MAPTNPC1RAB9A
SCHEMBL4248830 0.89 MAOB (0.60) MAOBALDH1A1MAPTNPC1RAB9A
SCHEMBL4250017 0.85 MAOB (0.62) MAOBALDH1A1MAPTNPC1RAB9A
SCHEMBL4253616 0.85 MAOB (0.74) MAOBMAPTAKR1B1LMNACYP3A4
SCHEMBL27635896 0.84 MAOB (0.83) MAOBALDH1A1MAPTAKR1B1TSHR
SCHEMBL4249323 0.83 MAOB (0.54) MAOBALDH1A1MAPTAKR1B1LMNA
SCHEMBL4250366 0.82 MAOB (0.55) MAOBALDH1A1MAPTAKR1B1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL MAOB 476/4885ALDH1A1 3157/4885MAPT 4765/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL MAOB 476/4885ALDH1A1 3157/4885MAPT 4765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.