SCHEMBL4258065

SCHEMBL4258065

CCCOC(=O)c1cc(=O)c2cc(N)ccc2o1

nearest known ligand 0.72

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.72
AKR1B1 P15121 2/20 0.51
EGFR P00533 1/20 0.46
SRC P12931 1/20 0.46
KMT2A Q03164 3/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
MEN1 O00255 2/20 0.46
ATM Q13315 1/20 0.46
MAPT P10636 3/20 0.45
SLC2A1 P11166 1/20 0.44
POLB P06746 2/20 0.44
ALDH1A1 P00352 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
GFER P55789 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
MAPK1 P28482 1/20 0.43
GAA P10253 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4258027 0.92 MAOB (0.62) MAOBAKR1B1EGFRSRCKMT2A
SCHEMBL4254462 0.91 MAOB (0.60) MAOBAKR1B1EGFRSRCKMT2A
SCHEMBL4247258 0.90 MAOB (0.59) MAOBAKR1B1EGFRSRCKMT2A
SCHEMBL4249673 0.90 MAOB (0.72) MAOBAKR1B1SRCKMT2AL3MBTL1
SCHEMBL4253616 0.89 MAOB (0.74) MAOBAKR1B1EGFRSRCKMT2A
SCHEMBL9635535 0.87 MAOB (0.72) MAOBAKR1B1KMT2AMEN1ATM
SCHEMBL4253738 0.84 MAOB (0.56) MAOBAKR1B1EGFRSRCKMT2A
SCHEMBL4250017 0.82 MAOB (0.62) MAOBAKR1B1SRCKMT2AL3MBTL1
SCHEMBL4246461 0.82 KDM4E (0.59) MAOBAKR1B1EGFRSRCMAPT
SCHEMBL4251638 0.82 MAOB (0.65) MAOBAKR1B1KMT2AL3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL MAOB 476/4885AKR1B1 237/4885EGFR 3027/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL MAOB 476/4885AKR1B1 237/4885EGFR 3027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.