⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1591982 | 0.84 | HTR6 (0.39) | — | |
| SCHEMBL19005858 | 0.80 | HTR6 (0.32) | — | |
| SCHEMBL4077331 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL6632484 | 0.67 | HTR6 (0.62) | — | |
| SCHEMBL8694678 | 0.65 | HTR6 (0.39) | — | |
| SCHEMBL337087 | 0.64 | HTR6 (0.65) | — | |
| SCHEMBL1874468 | 0.64 | — | — | |
| SCHEMBL20651315 | 0.62 | — | — | |
| SCHEMBL1591800 | 0.61 | HTR6 (0.35) | — | |
| SCHEMBL3383922 | 0.61 | HTR6 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247504-A1 | Indazole Derivatives for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
| EP-1983981-A1 | INDAZOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007088401-A1 | INDAZOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2007-08-09 | — | — | WO | disclosed |