SCHEMBL424774

SCHEMBL424774

N#Cc1ccc(OCCN2CCOCC2)cc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 6/20 0.79
HRH2 P25021 2/20 0.79
HRH1 P35367 2/20 0.79
NPC1 O15118 1/20 0.62
RAB9A P51151 1/20 0.62
LTA4H P09960 1/20 0.61
CA12 O43570 1/20 0.59
CA1 P00915 1/20 0.59
CA2 P00918 1/20 0.59
CA7 P43166 1/20 0.59
CA9 Q16790 1/20 0.59
ALDH1A1 P00352 2/20 0.59
MAPK1 P28482 2/20 0.59
CYP1A2 P05177 1/20 0.59
CHRM2 P08172 1/20 0.59
CHRM1 P11229 1/20 0.59
HTR2A P28223 1/20 0.59
SCN1A P35498 1/20 0.59
HTR2B P41595 1/20 0.59
KCNH2 Q12809 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7291468 0.92 HRH3 (0.92) HRH3HRH2HRH1ALDH1A1MAPK1
SCHEMBL8795398 0.91 HRH3 (0.84) HRH3HRH2HRH1ALDH1A1MAPK1
SCHEMBL1714312 0.89 HRH3 (0.71) HRH3HRH2HRH1KCNH2
SCHEMBL14714916 0.88 HRH3 (1.00) HRH3HRH2HRH1NPC1RAB9A
SCHEMBL4874490 0.85 HRH3 (0.82) HRH3HRH2HRH1LTA4HKDM4E
SCHEMBL3566247 0.84 NPC1 (0.62) HRH3HRH2HRH1NPC1RAB9A
SCHEMBL5214906 0.84 CA12 (0.63) HRH3HRH2HRH1NPC1RAB9A
SCHEMBL5623066 0.84 HRH3 (0.79) HRH3HRH2HRH1
SCHEMBL227297 0.84 HRH3 (0.85) HRH3HRH2HRH1LTA4H
SCHEMBL14577989 0.83 NPC1 (0.69) HRH3NPC1RAB9ALTA4HCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4682148-A2 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES AbbVie Ireland Unlimited Company (IE) 2026-01-21 EP disclosed
US-20250161318-A1 SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT ABBVIE INC (US) 2025-05-22 US disclosed
US-20250019364-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE INC. (US) 2025-01-16 US disclosed
EP-4474383-A2 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES AbbVie Ireland Unlimited Company (IE) 2024-12-11 EP disclosed
US-11897864-B2 Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases ABBVIE INC. (US) 2024-02-13 US disclosed
US-20240043404-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE INC. (US) 2024-02-08 US disclosed
EP-2435432-B3 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE IRELAND UNLIMITED CO (BM) 2023-10-25 EP disclosed
EP-4218731-A2 MELT-EXTRUDED SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT AbbVie Ireland Unlimited Company (IE) 2023-08-02 EP disclosed
US-20230143532-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE INC. (US) 2023-05-11 US disclosed
US-20220315555-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE INC. (US) 2022-10-06 US disclosed
WO-2009010488-A1 HETEROCYCLIC COMPOUNDS USEFUL AS MK2 INHIBITORS NOVARTIS AG (CH) 2009-01-22 WO disclosed
EP-1869088-A2 COMPOUNDS AND METHODS FOR PEPTIDE SYNTHESIS Biogen Idec MA Inc. (US) 2007-12-26 EP disclosed
WO-2006104922-A2 COMPOUNDS AND METHODS FOR PEPTIDE SYNTHESIS BIOGEN IDEC MA INC. (US) 2006-10-05 WO disclosed
US-6924284-B2 PARP inhibitors ICOS CORPORATION (US) 2005-08-02 US disclosed
US-20040087588-A1 Parp inhibitors ICOS CORPORATION 2004-05-06 US disclosed
US-6008226-A AN ENZYME INHIBITOR OF C-GMP-PHOSPHODIESTERASE FOR TREATING HEART FAILURE, HYPERTENSION, REVERSING OR REDUCING NITRATE-INDUCED TOLERANCE AND ANGINA PECTORIS, CONGESTIVE HEART DISEASE AND MYOCARDIAL INFARCTION SANOFI-SYNTHELABO (FR) 1999-12-28 US disclosed
EP-0813410-A4 SUBSTITUTED N-ARYLMETHYL AND HETEROCYCLYLMETHYL-1H-PYRAZOLO 3,4-b]QUINOLIN-4-AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF SANOFI WINTHROP INC (US) 1998-08-19 EP disclosed
EP-0813410-A1 SUBSTITUTED N-ARYLMETHYL AND HETEROCYCLYLMETHYL-1H-PYRAZOLO 3,4-b]QUINOLIN-4-AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF SANOFI WINTHROP, INC. (US) 1997-12-29 EP disclosed
US-5614530-A GMP PHOSPHODIESTERASE INHIBITOR, HYPOTENSIVE STERLING WINTHROP INC. (US) 1997-03-25 US disclosed
WO-1996028159-A1 SUBSTITUTED N-ARYLMETHYL AND HETEROCYCLYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4-AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF SANOFI WINTHROP, INC. (US) 1996-09-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040087588-A1 Parp inhibitors PARP1, PARP2, PARP11 HRH3 2457/4885HRH2 2971/4885HRH1 3050/4885
US-20230143532-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES BCL2, BAX, BCL3 HRH3 3491/4885HRH2 2813/4885HRH1 3698/4885
US-11897864-B2 Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases BCL2, BAX, BCL3 HRH3 3491/4885HRH2 2813/4885HRH1 3698/4885
US-20220315555-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES BCL2, BAX, BCL3 HRH3 3491/4885HRH2 2813/4885HRH1 3698/4885
US-20250019364-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES BCL2, BAX, BCL3 HRH3 3491/4885HRH2 2813/4885HRH1 3698/4885
US-20250161318-A1 SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT BCL2, BAX, BCL2L1 HRH3 4794/4885HRH2 4460/4885HRH1 4670/4885
US-20240043404-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES BCL2, BAX, BCL3 HRH3 3491/4885HRH2 2813/4885HRH1 3698/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.