Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 13/20 | 0.44 |
| ▸ | HTR2C | P28335 | 13/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4245602 | 0.89 | MEN1 (0.46) | MEN1ALDH1A1KMT2AHTR2AHTR2C | |
| SCHEMBL4251617 | 0.87 | HTR2A (0.49) | MEN1ALDH1A1KMT2AHTR2AHTR2C | |
| SCHEMBL4249394 | 0.76 | MEN1 (0.47) | MEN1ALDH1A1KMT2AHTR2AHTR2C | |
| SCHEMBL4245206 | 0.76 | HTR2A (0.40) | MEN1ALDH1A1KMT2AHTR2AHTR2C | |
| SCHEMBL4248244 | 0.75 | CACNA1G (0.51) | MEN1ALDH1A1KMT2AHTR2AHTR2C | |
| SCHEMBL4251622 | 0.74 | MEN1 (0.52) | MEN1ALDH1A1KMT2AHTR2AHTR2C | |
| SCHEMBL23328104 | 0.74 | HTR2A (0.61) | HTR2AHTR2CSLC6A4DRD2DRD3 | |
| SCHEMBL4252495 | 0.74 | CACNA1G (0.53) | MEN1ALDH1A1KMT2AHTR2AHTR2C | |
| SCHEMBL4252496 | 0.72 | MEN1 (0.49) | MEN1ALDH1A1KMT2AHTR2AHTR2C | |
| SCHEMBL4251700 | 0.72 | MAPT (0.42) | MEN1ALDH1A1KMT2AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1757590-B1 | Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof | KOREA INST SCI & TECH (KR) | 2009-12-02 | — | — | EP | claimed |
| US-7544686-B2 | Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-06-09 | — | — | US | claimed |
| EP-1757590-A1 | Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof | Korea Institute of Science and Technology (KR) | 2007-02-28 | — | — | EP | claimed |
| EP-1757590-B1 | Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof | KOREA INST SCI & TECH (KR) | 2009-12-02 | — | — | EP | disclosed |
| EP-1757590-A1 | Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof | Korea Institute of Science and Technology (KR) | 2007-02-28 | — | — | EP | disclosed |