Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL444842 | 0.91 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2TP53HPGDMAPT | |
| SCHEMBL4250980 | 0.84 | HDAC1 (0.45) | SMN1; SMN2TP53HPGDMAPTHDAC1 | |
| SCHEMBL4254292 | 0.83 | HDAC8 (0.42) | ALDH1A1SMN1; SMN2HPGDMAPTHDAC1 | |
| SCHEMBL4255202 | 0.82 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2TP53HPGDMAPT | |
| SCHEMBL4254244 | 0.82 | SMN1; SMN2 (0.60) | ALDH1A1SMN1; SMN2TP53HPGDMAPT | |
| SCHEMBL4251260 | 0.81 | HPGD (0.56) | ALDH1A1SMN1; SMN2TP53HPGDHDAC1 | |
| SCHEMBL4251111 | 0.78 | TAS1R3 (0.59) | ALDH1A1SMN1; SMN2MAPTMEN1NPC1 | |
| SCHEMBL444395 | 0.76 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2TP53HPGDMAPT | |
| SCHEMBL444394 | 0.76 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2TP53HPGDMAPT | |
| SCHEMBL443591 | 0.75 | HDAC1 (0.49) | SMN1; SMN2TP53HPGDMAPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | ALDH1A1 601/4885SMN1; SMN2 3469/4885TP53 2008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.