Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Traxoprodil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B known ✓ | Q13224 | 6/20 | 1.00 |
| ▸ | GRIN1 known ✓ | Q05586 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 3/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 3/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 3/20 | 1.00 |
| ▸ | GRIN3B | O60391 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.59 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | HTR2B | P41595 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Traxoprodil SCHEMBL5888841 | 1.00 | GRIN2B (1.00) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL6800343 | 1.00 | GRIN2B (1.00) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL8337144 | 1.00 | GRIN2B (1.00) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL6702711 | 1.00 | GRIN2B (1.00) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL5517640 | 1.00 | GRIN2B (1.00) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL8867900 | 0.99 | GRIN2B (0.97) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL8922418 | 0.99 | GRIN2B (0.97) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL8867888 | 0.99 | GRIN2B (0.97) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL27536541 | 0.93 | GRIN2B (0.86) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL7613753 | 0.93 | GRIN2B (0.86) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2751 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025264860-A2 | METHODS OF TREATING POST-COVID AIRWAY DISEASE | YALE UNIVERSITY (US) | 2025-12-26 | — | — | WO | claimed |
| EP-4629989-A2 | TREATMENT OR PREVENTION OF DEPRESSIVE DISORDERS THROUGH COMBINATION THERAPY | Freedom Biosciences, Inc. (US) | 2025-10-15 | — | — | EP | claimed |
| WO-2025202421-A1 | METHODS AND COMPOSITIONS | VRG 145 ZRT. (HU) | 2025-10-02 | — | — | WO | claimed |
| WO-2025134069-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS | ARIBIO CO., LTD. (KR) | 2025-06-26 | — | — | WO | claimed |
| US-20250161264-A1 | (AMPAR-PAM)-NMDA RECEPTOR ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF MENTAL CONDITIONS AND DISORDERS | GILGAMESH PHARMACEUTICALS, INC. | 2025-05-22 | — | — | US | claimed |
| EP-4547254-A1 | COMPOSITION FOR PREVENTING AND TREATING NEURODEGENERATIVE DISEASES | Aribio Co., Ltd (KR) | 2025-05-07 | — | — | EP | claimed |
| US-20250134894-A1 | COMPOSITIONS FOR PREVENTING AND TREATING NEURODEGENERATIVE DISEASES | ARIBIO CO LTD (KR) | 2025-05-01 | — | — | US | claimed |
| WO-2025065271-A1 | METHODS AND DEVICES FOR TREATING DEPRESSION | Liangzhu Laboratory (CN) | 2025-04-03 | — | — | WO | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| EP-4475953-A1 | NMDAR ANTAGONISTS PREVENT AGEING AND AGING-ASSOCIATED CONDITIONS AND DISEASES THROUGH INCREASING 20S PROTEASOME ACTIVITY | SAHIN, Fikret (TR) | 2024-12-18 | — | — | EP | claimed |
| WO-2000024395-A1 | NEW USE OF GLUTAMATE ANTAGONISTS FOR THE TREATMENT OF CANCER | IKONOMIDOU HRISSANTHI (DE) | 2000-05-04 | — | — | WO | claimed |
| US-6008233-A | TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM | PFIZER INC (US) | 1999-12-28 | — | — | US | claimed |
| WO-1999021539-A1 | METHOD FOR TREATING DISEASE-RELATED OR DRUG-INDUCED DYSKINESIAS | WARNER-LAMBERT COMPANY (US) | 1999-05-06 | — | — | WO | claimed |
| EP-0828513-A2 | COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS | PFIZER INC. (US) | 1998-03-18 | — | — | EP | claimed |
| US-5716961-A | Treatment of tinnitus using neuroprotective agents | PFIZER INC. (US) | 1998-02-10 | — | — | US | claimed |
| US-5710168-A | 2-piperidino-1-alkanol derivatives as neuroprotective agents | PFIZER INC. (US) | 1998-01-20 | — | — | US | claimed |
| EP-0768086-A1 | Treatment of tinnitus using neuroprotective agents | PFIZER INC. (US) | 1997-04-16 | — | — | EP | claimed |
| EP-0398578-B1 | 2-piperidino-1-alkanol derivatives as antiischemic agents | PFIZER (US) | 1997-03-12 | — | — | EP | claimed |
| WO-1996037226-A2 | COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS | PFIZER INC. (US) | 1996-11-28 | — | — | WO | claimed |
| US-5272160-A | 2-piperidino-1-alkanol derivatives as antiischemic agents | PFIZER INC (US) | 1993-12-21 | — | — | US | claimed |