Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Traxoprodil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B known ✓ | Q13224 | 6/20 | 1.00 |
| ▸ | GRIN1 known ✓ | Q05586 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 3/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 3/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 3/20 | 1.00 |
| ▸ | GRIN3B | O60391 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.59 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | HTR2B | P41595 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Traxoprodil SCHEMBL5888841 | 1.00 | GRIN2B (1.00) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL6800343 | 1.00 | GRIN2B (1.00) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL4248 | 1.00 | GRIN2B (1.00) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL8337144 | 1.00 | GRIN2B (1.00) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL6702711 | 1.00 | GRIN2B (1.00) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL8867900 | 0.99 | GRIN2B (0.97) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL8922418 | 0.99 | GRIN2B (0.97) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL8867888 | 0.99 | GRIN2B (0.97) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL27536541 | 0.93 | GRIN2B (0.86) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A | |
| Traxoprodil SCHEMBL7613753 | 0.93 | GRIN2B (0.86) | GRIN2BGRIN1CYP2D6GRIN2DGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006114703-A2 | METHOD OF ADMINISTRATION OF (1S,S2) -1- (4 -HYDROXYPHENYL) -2- (4-HYDR0XY-4-PHENYLPIPERIDIN-1-YL) -1- PROPANO (TRAXOPRODIL) | PFIZER PRODUCTS INC. (US) | 2006-11-02 | — | — | WO | claimed |
| CN-1273135-C | Pharmaceutical compositions of N-methyl-D-aspartate receptor antagonists | PFIZER PROD INC (US) | 2006-09-06 | — | — | CN | claimed |
| CN-1211366-C | Methyl sulfonate trihydrate of 1-(4-hydroxy phenyl)-2-(4-hydroxy-4-phenyl piperid-1-yl)-1-propanol and its intermidiate preparing process | PFIZER PROD INC (US) | 2005-07-20 | — | — | CN | claimed |
| CN-1210262-C | Method for preparing mesylate salt trihydrate of 1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol | PFIZER PROD INC (US) | 2005-07-13 | — | — | CN | claimed |
| JP-2005516036-A | — | — | 2005-06-02 | — | — | JP | claimed |
| CN-1615861-A | (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylipiperidin-1-yl)-1-propanolmethanesulfonate trihydrate | PFIZER (US) | 2005-05-18 | — | — | CN | claimed |
| EP-1497245-A1 | PROCESS FOR THE PREPARATION OF NONRACEMIC SYN-1-(4-HYDROXY-PHENYL)-2-(4-HYDROXY-4-PHENYL.PIPERIDIN-1Yl)-1-PROPANOL COMPOUNDS | DSM Pharmaceuticals, Inc. (US) | 2005-01-19 | — | — | EP | claimed |
| CN-1479617-A | N-methyl-D-aspartate receptor agonist pharmaceutical compositions | �Ʒ� | 2004-03-03 | — | — | CN | claimed |
| WO-2003062180-A1 | PROCESS FOR THE PREPARATION OF NONRACEMIC SYN-1-(4-HYDROXY-PHENYL)-2-(4-HYDROXY-4-PHENYL-PIPERIDIN-1-YL)-1-PROPANOL COMPOUNDS | DSM N.V. (NL) | 2003-07-31 | — | — | WO | claimed |
| WO-2003062181-A1 | PROCESS FOR THE PREPARATION OF NONRACEMIC SYN-1-(4-HYDROXY-PHENYL)-2-(4-HYDROXY-4-PHENYL.PIPERIDIN-1Yl)-1-PROPANOL COMPOUNDS | DSM PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |
| EP-1254661-A1 | Method for preventing dyskinesias with selective NMDA-Antagonists | WARNER-LAMBERT COMPANY (US) | 2002-11-06 | — | — | EP | claimed |
| CN-1322716-A | Methyl sulfonate trihydrate of 1-(4-hydroxy phenyl)-2-(4-hydroxy-4-phenyl piperid-1-yl)-1-propanol and its intermidiate preparing process | PFIZER PROD INC (US) | 2001-11-21 | — | — | CN | claimed |
| CN-1321638-A | Method for preparing mesylate salt trihydrate of 1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol | PFIZER PROD INC (US) | 2001-11-14 | — | — | CN | claimed |
| JP-2001520988-A | — | — | 2001-11-06 | — | — | JP | claimed |
| EP-1024799-A1 | METHOD FOR TREATING DISEASE-RELATED OR DRUG-INDUCED DYSKINESIAS | WARNER-LAMBERT COMPANY (US) | 2000-08-09 | — | — | EP | claimed |
| WO-1999021539-A1 | METHOD FOR TREATING DISEASE-RELATED OR DRUG-INDUCED DYSKINESIAS | WARNER-LAMBERT COMPANY (US) | 1999-05-06 | — | — | WO | claimed |
| CN-1198739-A | (1S,2S) -1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol mesylate trihydrate | PFIZER (US) | 1998-11-11 | — | — | CN | claimed |
| EP-0843661-A1 | (1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDIN-1-YL)-1-PROPANOLMETHANESULFONATE TRIHYDRATE | PFIZER INC. (US) | 1998-05-27 | — | — | EP | claimed |
| CN-1149454-A | Method for curing tinnitus by nerve protecting agent | PFIZER (US) | 1997-05-14 | — | — | CN | claimed |
| WO-1997007098-A1 | (1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDIN-1-YL)-1-PROPANOLMETHANESULFONATE TRIHYDRATE | PFIZER INC. (US) | 1997-02-27 | — | — | WO | claimed |