Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 10/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 10/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL444250 | 0.91 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL444248 | 0.91 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL444249 | 0.91 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL4247798 | 0.85 | HDAC3 (0.60) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL4252299 | 0.80 | HPGD (0.53) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL4248042 | 0.80 | HPGD (0.53) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL4254278 | 0.79 | HPGD (0.53) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL4255359 | 0.78 | TAS1R3 (0.52) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL444772 | 0.77 | HDAC3 (0.55) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL445805 | 0.77 | HDAC3 (0.63) | HDAC3HDAC1HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | HDAC3 3/4885HDAC1 1/4885HDAC2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.