Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | PRNP | P04156 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | OGG1 | O15527 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL443764 | 0.91 | HDAC1 (0.60) | HDAC1HDAC8HDAC6MAPTALDH1A1 | |
| SCHEMBL4252431 | 0.88 | NPC1 (0.46) | HDAC1HDAC8HDAC6MAPTALDH1A1 | |
| SCHEMBL445706 | 0.78 | NPC1 (0.52) | HDAC1HDAC8HDAC6MAPTALDH1A1 | |
| SCHEMBL4257390 | 0.78 | NPC1 (0.71) | HDAC1HDAC8HDAC6MAPTRAB9A | |
| SCHEMBL4252262 | 0.77 | HDAC1 (0.52) | HDAC1HDAC8HDAC6RAB9ASMN1; SMN2 | |
| SCHEMBL4255520 | 0.76 | SMN1; SMN2 (0.51) | HDAC1HDAC8HDAC6MAPTALDH1A1 | |
| SCHEMBL4252170 | 0.75 | HDAC8 (0.52) | HDAC1HDAC8HDAC6MAPTALDH1A1 | |
| SCHEMBL4250461 | 0.75 | NPC1 (0.57) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL4252991 | 0.75 | KMT2A (0.56) | HDAC1HDAC8HDAC6MAPTALDH1A1 | |
| SCHEMBL4251124 | 0.75 | SLC9A1 (0.41) | HDAC1HDAC8HDAC6MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | HDAC1 1/4885HDAC8 2/4885HDAC6 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.