Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.48 |
| ▸ | MAP3K8 | P41279 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 9/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054718 | 0.83 | MAP3K8 (0.62) | MAP2K1MAP3K8ICAM1SELEVCAM1 | |
| SCHEMBL4066932 | 0.78 | APP (0.49) | APPMAP2K1EGFRMAPK3MAPK1 | |
| SCHEMBL5312404 | 0.76 | ICAM1 (0.46) | MAP2K1MAP3K8MAPK1ICAM1SELE | |
| SCHEMBL27771625 | 0.73 | APP (0.58) | APPEGFR | |
| SCHEMBL4740142 | 0.71 | KDM4E (0.47) | ICAM1SELEVCAM1 | |
| SCHEMBL17167476 | 0.71 | APP (0.59) | APPMAP2K1MAPK3MAPK1 | |
| SCHEMBL27646466 | 0.70 | APP (0.50) | APPMAP2K1EGFRMAPK3MAPK1 | |
| SCHEMBL20004071 | 0.68 | SLC22A12 (0.51) | — | |
| SCHEMBL20783827 | 0.68 | APP (0.54) | APPEGFRSTK17B | |
| SCHEMBL12973253 | 0.68 | APP (1.00) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043654-A2 | THIENOPYRIMIDINES USEFUL AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals, Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146284-A2 | THIENOPYRIMIDINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-21 | — | — | WO | disclosed |