Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 1/20 | 0.46 |
| ▸ | SELE | P16581 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | MAP3K8 | P41279 | 10/20 | 0.46 |
| ▸ | PLK4 | O00444 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28083935 | 0.79 | HDAC3 (0.47) | MAPK1POLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL4740142 | 0.78 | KDM4E (0.47) | ICAM1SELEVCAM1LIMK1POLB | |
| SCHEMBL4248304 | 0.76 | APP (0.49) | ICAM1SELEVCAM1MAP3K8MAPK1 | |
| SCHEMBL5554204 | 0.73 | MAP3K8 (0.71) | ICAM1SELEVCAM1MAP3K8PIM1 | |
| SCHEMBL3708981 | 0.72 | ICAM1 (0.56) | ICAM1SELEVCAM1PLK4AURKA | |
| SCHEMBL13299937 | 0.72 | ESR1 (0.50) | MAPK1POLBRAB9AKDM4ENPC1 | |
| SCHEMBL1595609 | 0.70 | ICAM1 (0.47) | ICAM1SELEVCAM1MAP3K8CDK1 | |
| SCHEMBL23093512 | 0.69 | ICAM1 (0.57) | ICAM1SELEVCAM1PLK4AURKA | |
| SCHEMBL5333499 | 0.69 | ICAM1 (0.53) | ICAM1SELEVCAM1PIM1ALDH1A1 | |
| SCHEMBL30744177 | 0.69 | ICAM1 (0.57) | ICAM1SELEVCAM1PLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056215-A9 | N-ARYL-THIENOPYRIMIDIN-4-AMINES AND THE USE THEREOF | CYTOVIA INC (US) | 2007-09-13 | — | — | WO | disclosed |
| WO-2007056214-A2 | N-ALKYL-N-ARYL-THIENOPYRIMIDIN-R-AMINES AND USES THEREOF | CYTOVIA, INC (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056215-A2 | N-ARYL-THIENOPYRIMIDIN-4-AMINES AND THE USE THEREOF | CYTOVIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |