Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 13/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4239907 | 0.92 | MAPK11 (0.56) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL4240254 | 0.88 | MAPK11 (0.69) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL29594038 | 0.88 | MAPK11 (0.69) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL4237486 | 0.83 | MAPK11 (0.79) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL29593357 | 0.83 | MAPK11 (0.79) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL4243482 | 0.83 | MAPK13 (0.53) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL13928910 | 0.82 | MAPK11 (0.53) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL29593890 | 0.81 | MAPK11 (0.65) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL4241029 | 0.81 | MAPK11 (0.65) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL4243610 | 0.80 | MAPK11 (0.54) | MAPK11MAPK13CYP2C9MAPK14MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042856-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | ASTELLAS PHARMA INC (JP) | 2009-02-12 | — | — | US | disclosed |
| US-20090042856-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | ASTELLAS PHARMA INC (JP) | 2009-02-12 | — | — | US | disclosed |
| US-20090042856-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | ASTELLAS PHARMA INC (JP) | 2009-02-12 | — | — | US | disclosed |
| EP-1919919-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | Astellas Pharma Inc. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026950-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042856-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | HRH2, OPRD1, HRH4 | MAPK11 1195/4885MAPK13 1439/4885CYP2C9 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.