Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 12/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249890 | 0.89 | GPR35 (0.48) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4985501 | 0.85 | GPR35 (0.52) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4254106 | 0.85 | GPR35 (0.48) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4982799 | 0.84 | GPR35 (0.51) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4988768 | 0.81 | GPR35 (0.48) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4996718 | 0.81 | GPR35 (0.50) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4988853 | 0.81 | GPR35 (0.47) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4247593 | 0.77 | GPR35 (0.49) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4982825 | 0.76 | GPR35 (0.47) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4248701 | 0.75 | GPR35 (0.48) | GPR35KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170851-A1 | Chroman Compounds | BERNSTEIN PETER | 2009-07-02 | — | — | US | disclosed |
| EP-1945624-A1 | CHROMAN COMPOUNDS AS 5-HT1B ANTAGONISTS | Astra Zeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| US-20070185107-A1 | Chroman compounds | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
| US-20070135442-A1 | Chroman compounds | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | US | disclosed |
| WO-2007053095-A1 | CHROMAN COMPOUNDS AS 5-HT1B ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007053094-A1 | CHROMAN COMPOUNDS AS 5 -HTlB ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135442-A1 | Chroman compounds | CYP3A43, CYP2C9, CYP2C8 | GPR35 1756/4885KDM4E 2353/4885ALDH1A1 1546/4885 |
| US-20090170851-A1 | Chroman Compounds | CYP3A43, CYP2C9, CYP2C8 | GPR35 1814/4885KDM4E 2050/4885ALDH1A1 1638/4885 |
| US-20070185107-A1 | Chroman compounds | CYP3A43, CYP2C9, CYP2C8 | GPR35 1814/4885KDM4E 2050/4885ALDH1A1 1638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.