Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 2/20 | 0.52 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2705962 | 0.79 | PSEN1 (0.53) | KCNN4KCNA3PSEN1PSEN2APH1B | |
| SCHEMBL8136017 | 0.79 | KCNN4 (0.52) | KCNN4KCNA3PSEN1PSEN2APH1B | |
| SCHEMBL2702464 | 0.77 | PSEN1 (0.64) | KCNN4KCNA3PSEN1PSEN2APH1B | |
| SCHEMBL2704352 | 0.76 | PSEN1 (0.63) | KCNN4KCNA3PSEN1PSEN2APH1B | |
| SCHEMBL2703650 | 0.75 | PSEN1 (0.64) | KCNN4KCNA3PSEN1PSEN2APH1B | |
| SCHEMBL2705149 | 0.73 | PSEN1 (0.61) | KCNN4KCNA3PSEN1PSEN2APH1B | |
| SCHEMBL2704928 | 0.73 | KCNN4 (0.53) | KCNN4KCNA3PSEN1PSEN2APH1B | |
| SCHEMBL2703814 | 0.72 | PSEN1 (0.63) | KCNN4KCNA3PSEN1PSEN2APH1B | |
| SCHEMBL28665779 | 0.71 | KCNA3 (0.89) | KCNN4KCNA3PSEN1PSEN2APH1B | |
| SCHEMBL8135760 | 0.71 | KCNA3 (0.62) | KCNN4KCNA3PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038280-A2 | FUSED, TRICYCLIC SULFONAMIDE INHIBITORS OF GAMMA SECRETASE | Elan Pharmaceuticals Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007143523-A2 | FUSED, TRICYCLIC SULFONAMIDE INHIBITORS OF GAMMA SECRETASE | ELAN PHARMACEUTICALS, INC. (US) | 2007-12-13 | — | — | WO | disclosed |