Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | TTK | P33981 | 5/20 | 0.51 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 5/20 | 0.51 |
| ▸ | JAK1 | P23458 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | BTK | Q06187 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4256785 | 0.87 | JAK2 (0.57) | JAK2BRD4TTKFLT3CCNE1 | |
| SCHEMBL3971076 | 0.86 | TTK (0.66) | JAK2BRD4TTKJAK3JAK1 | |
| SCHEMBL14547962 | 0.80 | JAK2 (0.57) | JAK2BRD4TTKFLT3CCNE1 | |
| SCHEMBL3970170 | 0.80 | TTK (0.51) | JAK2BRD4TTKFLT3CCNE1 | |
| SCHEMBL3974456 | 0.79 | TTK (0.50) | JAK2BRD4TTKFLT3CCNE1 | |
| SCHEMBL3970607 | 0.78 | TTK (0.49) | JAK2BRD4TTKFLT3CCNE1 | |
| SCHEMBL3975590 | 0.77 | TTK (0.48) | JAK2BRD4TTKFLT3CCNE1 | |
| SCHEMBL3971558 | 0.76 | TTK (0.47) | JAK2BRD4TTKFLT3CCNE1 | |
| SCHEMBL13883885 | 0.76 | TTK (0.47) | JAK2BRD4TTKFLT3CCNE1 | |
| SCHEMBL30347270 | 0.76 | TTK (0.49) | JAK2BRD4TTKFLT3CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |