Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 7/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.45 |
| ▸ | CDK9 | P50750 | 4/20 | 0.45 |
| ▸ | CDK1 | P06493 | 3/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.45 |
| ▸ | CDK7 | P50613 | 3/20 | 0.45 |
| ▸ | CCNH | P51946 | 3/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972657 | 0.91 | CCNA2 (0.47) | TTKPTK2CDK2CCNT1CCNA2 | |
| SCHEMBL3970291 | 0.90 | TTK (0.63) | TTKJAK2BRD4PTK2FLT3 | |
| SCHEMBL3971647 | 0.85 | PDPK1 (0.47) | TTKJAK2BRD4PTK2CDK2 | |
| SCHEMBL3975590 | 0.84 | TTK (0.48) | TTKJAK2BRD4PTK2CDK2 | |
| SCHEMBL3971363 | 0.84 | TTK (0.46) | TTKJAK2BRD4PTK2CDK2 | |
| SCHEMBL13883513 | 0.84 | PDE5A (0.49) | TTKJAK2BRD4CDK2CCNT1 | |
| SCHEMBL13883562 | 0.84 | IRAK4 (0.49) | CDK2CCNT1CCNA2CDK9CDK1 | |
| SCHEMBL3966581 | 0.83 | JAK2 (0.51) | TTKJAK2BRD4PTK2EGFR | |
| SCHEMBL3974456 | 0.83 | TTK (0.50) | TTKJAK2BRD4PTK2CDK2 | |
| SCHEMBL3971558 | 0.82 | TTK (0.47) | TTKJAK2BRD4PTK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |