Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.53 |
| ▸ | HTR2A | P28223 | 10/20 | 0.53 |
| ▸ | HTR2B | P41595 | 9/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015795 | 0.82 | HTR2C (0.71) | HTR2CHTR2AHTR2BHTR6MLNR | |
| SCHEMBL4006035 | 0.81 | HTR2C (0.69) | HTR2CHTR2AHTR2BHTR6MLNR | |
| SCHEMBL4010697 | 0.81 | HTR2C (0.69) | HTR2CHTR2AHTR2BHTR6MLNR | |
| SCHEMBL4009889 | 0.79 | HTR2A (0.39) | HTR2CHTR2ADGAT2 | |
| SCHEMBL4203438 | 0.79 | HTR2A (0.52) | HTR2CHTR2AMAP4K4CYP2D6 | |
| SCHEMBL4010604 | 0.78 | HTR2C (0.75) | HTR2CHTR2AHTR2BHTR6 | |
| SCHEMBL4015920 | 0.77 | HTR2C (0.79) | HTR2CHTR2AHTR2BHTR6 | |
| SCHEMBL4010686 | 0.77 | HTR2C (0.60) | HTR2CHTR2AHTR2BHTR6MLNR | |
| SCHEMBL4207589 | 0.76 | HTR2C (0.56) | HTR2CHTR2AHTR6 | |
| SCHEMBL4353943 | 0.76 | HTR2C (0.49) | HTR2CHTR2AHTR6MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094695-A1 | TETRAHYDRO-5H-PYRIDO[2,3-D]AZEPINES AS 5-HT2C LIGANDS | Cascade Therapeutics Inc. (CA) | 2009-09-02 | — | — | EP | claimed |
| WO-2008009125-A1 | TETRAHYDRO-5H-PYRIDO[2,3-D]AZEPINES AS 5-HT2C LIGANDS | CASCADE THERAPEUTICS INC. (CA) | 2008-01-24 | — | — | WO | claimed |