Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.45 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDE6D | O43924 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4251900 | 0.94 | KIF11 (0.46) | KIF11KIF23TMEM97SIGMAR1MAP1LC3B | |
| SCHEMBL4249023 | 0.94 | KIF11 (0.52) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4248841 | 0.94 | KIF11 (0.47) | KIF11KIF23TMEM97SIGMAR1MAP1LC3B | |
| SCHEMBL4249025 | 0.94 | KIF11 (0.52) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4248271 | 0.93 | KIF11 (0.47) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4252363 | 0.92 | KIF11 (0.46) | KIF11KIF23SIGMAR1MAP1LC3BCYP3A4 | |
| SCHEMBL4252114 | 0.91 | KIF11 (0.53) | KIF11 | |
| SCHEMBL4252111 | 0.91 | KIF11 (0.53) | KIF11 | |
| SCHEMBL4248040 | 0.88 | KIF11 (0.47) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4251488 | 0.87 | KIF11 (0.47) | KIF11TMEM97SIGMAR1MAP1LC3BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035426-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007144384-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2007-12-21 | — | — | WO | disclosed |