Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4251448 | 0.90 | ALDH1A1 (0.41) | ALDH1A1HPGDC5AR1BRD4TSHR | |
| SCHEMBL4248183 | 0.88 | ALDH1A1 (0.42) | ALDH1A1HPGDC5AR1BRD4TSHR | |
| SCHEMBL4252104 | 0.83 | HPGD (0.41) | ALDH1A1HPGDC5AR1TSHRKDM4E | |
| SCHEMBL4250501 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HPGDC5AR1BRD4TSHR | |
| SCHEMBL4248252 | 0.81 | HPGD (0.44) | ALDH1A1HPGDC5AR1TSHRKDM4E | |
| SCHEMBL4248253 | 0.81 | HPGD (0.44) | ALDH1A1HPGDC5AR1TSHRKDM4E | |
| SCHEMBL4247299 | 0.81 | ALDH1A1 (0.50) | ALDH1A1HPGDC5AR1BRD4TSHR | |
| SCHEMBL4249080 | 0.81 | KDM4E (0.40) | ALDH1A1HPGDTSHRKDM4EHTT | |
| SCHEMBL4247898 | 0.79 | HPGD (0.44) | ALDH1A1HPGDC5AR1TSHRKDM4E | |
| SCHEMBL4247900 | 0.79 | HPGD (0.44) | ALDH1A1HPGDC5AR1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035426-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007144384-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2007-12-21 | — | — | WO | disclosed |