Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.86 |
| ▸ | MMP9 | P14780 | 3/20 | 0.86 |
| ▸ | MMP8 | P22894 | 3/20 | 0.86 |
| ▸ | MMP13 | P45452 | 2/20 | 0.86 |
| ▸ | MAPT | P10636 | 8/20 | 0.63 |
| ▸ | TP53 | P04637 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | COMT | P21964 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16148237 | 0.87 | MMP2 (0.76) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL17498813 | 0.83 | MMP2 (0.83) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL17498823 | 0.81 | MMP2 (0.71) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL16147276 | 0.81 | MMP2 (0.78) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL16147075 | 0.81 | MMP2 (0.78) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL17498766 | 0.79 | MMP2 (0.71) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL17498759 | 0.79 | MMP2 (0.74) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL17498751 | 0.79 | MMP2 (0.67) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL4562905 | 0.77 | MMP2 (0.56) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL17498726 | 0.77 | MMP2 (0.64) | MMP2MMP9MMP8MMP13MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111837-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN | PFIZER INC. | 2009-04-30 | — | — | US | disclosed |
| EP-1855686-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN | Pfizer Limited (GB) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006092691-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN | PFIZER LIMITED (GB) | 2006-09-08 | — | — | WO | disclosed |
| WO-2006092692-A1 | USE OF COMBINATIONS OF PDE7 INHIBITORS AND ALPHA-2-DELTY LIGANDS FOR THE TREATMENT OF NEUROPATHIC PAIN | PFIZER LIMITED (GB) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111837-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN | PDE7A, PDE7B, PDE3A | MMP2 420/4885MMP9 477/4885MMP8 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.