Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.73 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13702012 | 0.93 | EPHX2 (0.75) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4249396 | 0.88 | EPHX2 (0.80) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4252964 | 0.88 | EPHX2 (0.74) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4253820 | 0.86 | EPHX2 (0.77) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4254021 | 0.86 | EPHX2 (0.71) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4255999 | 0.86 | EPHX2 (0.71) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL14507597 | 0.85 | EPHX2 (0.80) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL13701922 | 0.85 | EPHX2 (0.79) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL14507632 | 0.85 | EPHX2 (0.74) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4250879 | 0.84 | EPHX2 (0.84) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | EPHX1, EPHX2, EPX | EPHX2 2/4885ALOX5 60/4885TBXAS1 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.