Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 3/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 2/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.31 |
| ▸ | PAK4 | O96013 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | LTK | P29376 | 2/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964284 | 0.90 | JAK2 (0.37) | JAK2JAK1TTKLMNAL3MBTL1 | |
| SCHEMBL4081376 | 0.87 | JAK2 (0.40) | JAK2JAK1TTKLMNAL3MBTL1 | |
| SCHEMBL13883576 | 0.79 | JAK2 (0.40) | JAK2JAK1TTKLMNAL3MBTL1 | |
| SCHEMBL13883557 | 0.78 | IKBKB (0.40) | JAK2JAK1TTKLMNAL3MBTL1 | |
| SCHEMBL4077621 | 0.78 | JAK2 (0.37) | JAK2JAK1TTKLMNAL3MBTL1 | |
| SCHEMBL13883496 | 0.78 | JAK2 (0.38) | JAK2JAK1TTKLMNAL3MBTL1 | |
| SCHEMBL4255795 | 0.76 | JAK1 (0.38) | JAK2JAK1TTKLMNAL3MBTL1 | |
| SCHEMBL3973621 | 0.76 | JAK2 (0.38) | JAK2JAK1TTKLMNAL3MBTL1 | |
| SCHEMBL4251723 | 0.76 | JAK2 (0.46) | JAK2JAK1TTKLMNAL3MBTL1 | |
| SCHEMBL13883718 | 0.75 | AXL (0.38) | JAK2JAK1TTKTNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |