Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | JAK1 | P23458 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 2/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964284 | 0.89 | JAK2 (0.37) | JAK2JAK1LMNAL3MBTL1HTR1A | |
| SCHEMBL4249790 | 0.87 | JAK2 (0.38) | JAK2JAK1LMNAL3MBTL1HTR1A | |
| SCHEMBL13883551 | 0.85 | TUBB4A (0.41) | JAK2JAK1TTKTUBB4ATUBB | |
| SCHEMBL13883576 | 0.85 | JAK2 (0.40) | JAK2JAK1LMNAL3MBTL1TTK | |
| SCHEMBL13883586 | 0.85 | CYP11B1 (0.42) | JAK1TTK | |
| Hydrochloric Acid SCHEMBL4080579 | 0.84 | TUBB4A (0.41) | JAK2JAK1TTKTUBB4ATUBB | |
| SCHEMBL13883557 | 0.83 | IKBKB (0.40) | JAK2JAK1LMNAL3MBTL1TTK | |
| SCHEMBL13883496 | 0.83 | JAK2 (0.38) | JAK2JAK1LMNAL3MBTL1HTR1A | |
| SCHEMBL3969173 | 0.83 | TTK (0.40) | JAK2JAK1L3MBTL1TTKPTK2 | |
| SCHEMBL3967492 | 0.82 | MAPK1 (0.41) | JAK2JAK1L3MBTL1TTKPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | claimed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |