Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.63 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249803 | 0.85 | EPHX2 (0.63) | EPHX2PTGER1KDM4ELDHAALDH1A1 | |
| SCHEMBL4252960 | 0.85 | EPHX2 (0.63) | EPHX2PTGER1KDM4ELDHAALDH1A1 | |
| SCHEMBL4245873 | 0.85 | EPHX2 (0.63) | EPHX2PTGER1KDM4ELDHAALDH1A1 | |
| SCHEMBL4250848 | 0.80 | EPHX2 (0.62) | EPHX2PTGER1KDM4ELDHAALDH1A1 | |
| SCHEMBL4252882 | 0.79 | EPHX2 (0.67) | EPHX2PTGER1KDM4ELDHAALDH1A1 | |
| SCHEMBL4252700 | 0.78 | EPHX2 (0.53) | EPHX2PTGER1KDM4ELDHAALDH1A1 | |
| SCHEMBL4389540 | 0.78 | EPHX2 (1.00) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL14507847 | 0.77 | EPHX2 (0.64) | EPHX2KDM4EALDH1A1HSP90AA1ALOX5 | |
| SCHEMBL14507636 | 0.77 | EPHX2 (0.73) | EPHX2PTGER1KDM4ELDHAALDH1A1 | |
| SCHEMBL4246786 | 0.76 | EPHX2 (0.58) | EPHX2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
| EP-1960367-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007067836-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | EPHX1, EPHX2, EPX | EPHX2 2/4885PTGER1 69/4885KDM4E 1988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.