Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 5/20 | 0.58 |
| ▸ | MAOA | P21397 | 3/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.54 |
| ▸ | MTOR | P42345 | 5/20 | 0.50 |
| ▸ | PIM1 | P11309 | 5/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 1/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4250156 | 1.00 | CISD1 (0.58) | CISD1MAOAGSK3BPIK3CGMTOR | |
| SCHEMBL13745894 | 0.99 | CISD1 (0.59) | CISD1MAOAGSK3BPIK3CGMTOR | |
| SCHEMBL4258413 | 0.87 | GSK3B (0.59) | CISD1MAOAGSK3BPIK3CGMTOR | |
| SCHEMBL4258410 | 0.87 | GSK3B (0.59) | CISD1MAOAGSK3BPIK3CGMTOR | |
| SCHEMBL13745378 | 0.81 | PIK3CG (0.53) | CISD1MAOAGSK3BPIK3CGMTOR | |
| SCHEMBL14852239 | 0.80 | PIM1 (0.72) | PIK3CGMTORPIM1NPC1RAB9A | |
| SCHEMBL4251796 | 0.78 | PIK3CG (0.57) | CISD1MAOAGSK3BPIK3CGMTOR | |
| SCHEMBL4253633 | 0.78 | PIK3CG (0.57) | CISD1MAOAGSK3BPIK3CGMTOR | |
| SCHEMBL4254853 | 0.78 | RAB9A (0.59) | CISD1MAOAGSK3BPIK3CGMTOR | |
| SCHEMBL4253630 | 0.78 | PIK3CG (0.57) | CISD1MAOAGSK3BPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215818-A1 | THIOZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-27 | — | — | US | claimed |
| US-20090215818-A1 | THIOZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215818-A1 | THIOZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | PIK3CD, PI4KA, PIP4K2A | CISD1 3668/4885MAOA 3932/4885GSK3B 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.