SCHEMBL4250271

SCHEMBL4250271

O=C(O)/C=C(\Oc1ccccc1[N+](=O)[O-])C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.48
ALDH1A1 P00352 5/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
TDP1 Q9NUW8 2/20 0.47
MAPT P10636 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.46
RAB9A P51151 3/20 0.46
NPC1 O15118 1/20 0.46
RECQL P46063 1/20 0.46
ESR2 Q92731 1/20 0.45
HTT P42858 1/20 0.44
POLB P06746 3/20 0.44
KCNH2 Q12809 1/20 0.44
HPGD P15428 1/20 0.43
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4250277 1.00 KDM4E (0.48) KDM4EALDH1A1MEN1KMT2ATDP1
SCHEMBL4251655 1.00 KDM4E (0.48) KDM4EALDH1A1MEN1KMT2ATDP1
SCHEMBL31694579 0.79 ALDH1A1 (0.55) KDM4EALDH1A1MEN1KMT2ATDP1
SCHEMBL57738 0.79 ALDH1A1 (0.58) KDM4EALDH1A1MEN1KMT2ATDP1
SCHEMBL57737 0.79 ALDH1A1 (0.58) KDM4EALDH1A1MEN1KMT2ATDP1
SCHEMBL19744074 0.78 SMN1; SMN2 (0.46) KDM4EALDH1A1KMT2ATDP1MAPT
SCHEMBL19743940 0.78 SMN1; SMN2 (0.46) KDM4EALDH1A1KMT2ATDP1MAPT
Bicarbonate SCHEMBL18955378 0.77 ALDH1A1 (0.56) KDM4EALDH1A1MEN1KMT2ATDP1
Bicarbonate SCHEMBL18955379 0.77 ALDH1A1 (0.56) KDM4EALDH1A1MEN1KMT2ATDP1
SCHEMBL3794216 0.77 MEN1 (0.55) KDM4EALDH1A1MEN1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL KDM4E 978/4885ALDH1A1 3157/4885MEN1 1358/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL KDM4E 978/4885ALDH1A1 3157/4885MEN1 1358/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.