Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.48 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.48 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29107173 | 0.88 | MEN1 (0.55) | GAAHDAC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL30702269 | 0.88 | MEN1 (0.55) | GAAHDAC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8383166 | 0.80 | NPC1 (0.56) | GAASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL30702271 | 0.78 | MEN1 (0.48) | GAAHDAC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL29107193 | 0.78 | MEN1 (0.48) | GAAHDAC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1886334 | 0.78 | HDAC1 (0.83) | GAAHDAC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1891506 | 0.75 | HDAC1 (1.00) | GAAHDAC1SMN1; SMN2SHMT2 | |
| SCHEMBL13491713 | 0.74 | NPC1 (0.60) | GAAHDAC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4315507 | 0.74 | MEN1 (0.58) | GAASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL3649343 | 0.73 | GAA (0.71) | GAASMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677731-A4 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA INC (US) | 2009-05-06 | — | — | EP | claimed |
| EP-1677731-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | Aton Pharma, Inc. (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005034880-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA, INC. (US) | 2005-04-21 | — | — | WO | claimed |