SCHEMBL4251694

SCHEMBL4251694

COC(=O)[C@]1(C)OC[C@H](Cc2ccc(OCc3nc(C(C)(C)C)oc3C)cc2)CO1

nearest known ligand 0.70

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 14/20 0.70
PPARG P37231 13/20 0.70
FFAR1 O14842 1/20 0.38
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
MAPT P10636 1/20 0.35
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4254644 1.00 PPARA (0.70) PPARAPPARGFFAR1NPC1RAB9A
SCHEMBL4248436 0.92 PPARA (0.83) PPARAPPARG
SCHEMBL4246485 0.92 PPARA (0.83) PPARAPPARG
SCHEMBL4249420 0.91 PPARA (0.84) PPARAPPARGFFAR1
SCHEMBL4248148 0.91 PPARA (0.84) PPARAPPARGFFAR1
SCHEMBL4249419 0.91 PPARA (0.84) PPARAPPARGFFAR1
SCHEMBL4251754 0.88 PPARA (0.54) PPARAPPARGFFAR1MAPTPOLB
SCHEMBL4243333 0.88 PPARA (0.54) PPARAPPARGFFAR1MAPTPOLB
SCHEMBL4248805 0.84 PPARA (0.85) PPARAPPARGFFAR1MAPT
SCHEMBL4243484 0.84 PPARA (0.85) PPARAPPARGFFAR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090012069-A1 Novel Antidiabetic Compounds CADILA HEALTHCARE LIMITED (IN) 2009-01-08 US claimed
US-20090012069-A1 Novel Antidiabetic Compounds CADILA HEALTHCARE LIMITED (IN) 2009-01-08 US disclosed
EP-1781633-A1 NOVEL ANTIDIABETIC COMPOUNDS CADILA HEALTHCARE LIMITED (IN) 2007-05-09 EP disclosed
WO-2006018855-A1 NOVEL ANTIDIABETIC COMPOUNDS CADILA HEALTHCARE LIMITED (IN) 2006-02-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012069-A1 Novel Antidiabetic Compounds GPR119, SLC5A1, SLC5A2 PPARA 145/4885PPARG 76/4885FFAR1 405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.