Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3296727 | 1.00 | HTR6 (0.41) | HTR6PLA2G10IKBKBCHUKPLA2G2A | |
| SCHEMBL3295270 | 0.86 | F10 (0.47) | PLA2G10IKBKBCHUKPLA2G2ACCR2 | |
| Hydrochloric Acid SCHEMBL3297425 | 0.85 | F10 (0.46) | PLA2G10IKBKBCHUKPLA2G2ACCR2 | |
| SCHEMBL3299508 | 0.84 | F10 (0.42) | HTR6PLA2G10IKBKBCHUKCCR2 | |
| SCHEMBL3297073 | 0.84 | SLC6A2 (0.42) | HTR6CCR2F10KCNH2HTR1A | |
| SCHEMBL3296497 | 0.83 | F10 (0.46) | HTR6PLA2G10CCR2F10HTR1A | |
| Hydrochloric Acid SCHEMBL3304349 | 0.83 | F10 (0.41) | HTR6PLA2G10IKBKBCHUKCCR2 | |
| Hydrochloric Acid SCHEMBL3297955 | 0.83 | SLC6A2 (0.42) | HTR6CCR2F10KCNH2HTR1A | |
| Hydrochloric Acid SCHEMBL3295163 | 0.82 | F10 (0.45) | HTR6PLA2G10CCR2F10HTR1A | |
| SCHEMBL3298934 | 0.80 | HTR6 (0.45) | HTR6PLA2G10CCR2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084131-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008055808-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |