SCHEMBL4252003

SCHEMBL4252003

COOC(=O)c1cc(=O)c2cccc([N+](=O)[O-])c2o1

nearest known ligand 0.69

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 11/20 0.69
LMNA P02545 2/20 0.49
MAOB P27338 1/20 0.40
ALDH1A1 P00352 3/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
GAA P10253 2/20 0.38
AKR1C4 P17516 1/20 0.38
AKR1C3 P42330 1/20 0.38
AKR1C2 P52895 1/20 0.38
AKR1C1 Q04828 1/20 0.38
MAPT P10636 3/20 0.38
PKM P14618 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
RAB9A P51151 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
TDP1 Q9NUW8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4254530 0.90 GPR35 (0.72) GPR35LMNAALDH1A1MEN1KMT2A
SCHEMBL4249992 0.87 GPR35 (0.67) GPR35LMNAMAOBALDH1A1MEN1
SCHEMBL4250424 0.85 GPR35 (0.69) GPR35LMNAMAOBALDH1A1MEN1
SCHEMBL4256024 0.85 GPR35 (0.65) GPR35LMNAMAOBALDH1A1MEN1
SCHEMBL4250503 0.84 GPR35 (0.67) GPR35LMNAMAOBALDH1A1MEN1
SCHEMBL4253678 0.84 GPR35 (0.63) GPR35LMNAMAOBALDH1A1MAPT
SCHEMBL4251271 0.83 GPR35 (0.62) GPR35LMNAMAOBALDH1A1MAPT
SCHEMBL4247919 0.82 GPR35 (0.65) GPR35LMNAMAOBALDH1A1MEN1
SCHEMBL4258050 0.82 GPR35 (0.61) GPR35LMNAMAOBALDH1A1MAPT
SCHEMBL4250005 0.82 GPR35 (1.00) GPR35LMNAALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL GPR35 2693/4885LMNA 1091/4885MAOB 476/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL GPR35 2693/4885LMNA 1091/4885MAOB 476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.