Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL444696 | 0.90 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4ETSHRNPC1RAB9A | |
| SCHEMBL4251688 | 0.81 | MAPT (0.58) | SMN1; SMN2KDM4ENPC1RAB9AMEN1 | |
| SCHEMBL4250389 | 0.81 | RAB9A (0.56) | SMN1; SMN2TSHRNPC1RAB9AALDH1A1 | |
| SCHEMBL4257390 | 0.79 | NPC1 (0.71) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4251979 | 0.78 | PDE10A (0.47) | NPC1ALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL4252170 | 0.77 | HDAC8 (0.52) | SMN1; SMN2NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL4253855 | 0.77 | HDAC6 (0.47) | SMN1; SMN2KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL4251122 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1MAPK1GAAHSD17B10 | |
| SCHEMBL4252991 | 0.77 | KMT2A (0.56) | SMN1; SMN2KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL4251239 | 0.76 | POLB (0.49) | SMN1; SMN2TSHRNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | SMN1; SMN2 3469/4885KDM4E 369/4885TSHR 2266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.