Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 3/20 | 0.39 |
| ▸ | PPARA | Q07869 | 5/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 6/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 2/20 | 0.32 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2809747 | 0.83 | KMT2A (0.41) | SERPINE1PPARAABCB11CYP1A2CYP3A4 | |
| SCHEMBL2806751 | 0.80 | SERPINE1 (0.49) | SERPINE1PPARAPPARGEDNRBMEN1 | |
| SCHEMBL2810361 | 0.76 | SERPINE1 (0.51) | SERPINE1PPARGEDNRBMEN1USP2 | |
| SCHEMBL12860016 | 0.74 | PPARA (0.59) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL2810186 | 0.73 | SERPINE1 (0.54) | SERPINE1PPARGEDNRBPTGESMEN1 | |
| SCHEMBL2805777 | 0.72 | SERPINE1 (0.42) | SERPINE1PPARGEDNRBMEN1ALDH1A1 | |
| SCHEMBL13168276 | 0.72 | PIN1 (0.42) | SERPINE1PPARGEDNRBMEN1ALDH1A1 | |
| SCHEMBL2807928 | 0.72 | KDM4E (0.44) | SERPINE1TSHRPPARGTP53MEN1 | |
| SCHEMBL13168630 | 0.71 | PIN1 (0.44) | SERPINE1EDNRBMEN1USP2ALDH1A1 | |
| SCHEMBL2813528 | 0.71 | SERPINE1 (0.50) | SERPINE1PPARAPPARGEDNRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081894-A1 | 1H-INDOLE-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS PPAR MODULATORS | SmithKline Beecham Corporation (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008028118-A1 | 1H-INDOLE-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS PPAR MODULATORS | SMITHKLINE BEECHAM CORPORAITON (US) | 2008-03-06 | — | — | WO | disclosed |