Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.54 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.54 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1998890 | 0.84 | CYP1A2 (1.00) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL29457697 | 0.84 | CYP1A2 (1.00) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL29580184 | 0.84 | CYP1A2 (1.00) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL8923677 | 0.79 | CYP1A2 (0.76) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL8544041 | 0.79 | CYP1A2 (0.79) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL8542210 | 0.76 | KDM4E (0.61) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL8784175 | 0.76 | CYP1A2 (0.84) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL8783900 | 0.76 | CYP1A2 (0.84) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL8924229 | 0.76 | CYP1A2 (0.69) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL8784335 | 0.74 | CYP1A2 (0.82) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090004112-A1 | METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES USING NMDA RECEPTOR GLYCINE SITE ANTAGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090004112-A1 | METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES USING NMDA RECEPTOR GLYCINE SITE ANTAGONISTS | GRIN2A, GRIN2B, GRIN2D | CYP1A2 4820/4885KDM4E 2103/4885MEN1 4391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.