SCHEMBL29457697

SCHEMBL29457697

O=c1[nH]c2cc(Cl)ccc2c(O)c1-c1cccc(Oc2ccccc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 1.00
KDM4E B2RXH2 1/20 1.00
MEN1 O00255 1/20 1.00
CYP2D6 P10635 1/20 1.00
CYP2C19 P33261 1/20 1.00
KMT2A Q03164 1/20 1.00
HSD17B10 Q99714 1/20 1.00
POLB P06746 1/20 0.83
CYP3A4 P08684 1/20 0.83
CYP2C9 P11712 1/20 0.83
TSHR P16473 1/20 0.83
BLM P54132 1/20 0.83
GRIN2D O15399 3/20 0.69
GRIN3B O60391 3/20 0.69
GRIN1 Q05586 3/20 0.69
GRIN2A Q12879 3/20 0.69
GRIN2B Q13224 3/20 0.69
GRIN2C Q14957 3/20 0.69
GRIN3A Q8TCU5 3/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29580184 1.00 CYP1A2 (1.00) CYP1A2KDM4EMEN1CYP2D6CYP2C19
SCHEMBL1998890 1.00 CYP1A2 (1.00) CYP1A2KDM4EMEN1CYP2D6CYP2C19
SCHEMBL8783900 0.91 CYP1A2 (0.84) CYP1A2KDM4EMEN1CYP2D6CYP2C19
SCHEMBL8784175 0.91 CYP1A2 (0.84) CYP1A2KDM4EMEN1CYP2D6CYP2C19
SCHEMBL8784124 0.91 CYP1A2 (1.00) CYP1A2KDM4EMEN1CYP2D6CYP2C19
SCHEMBL8784335 0.90 CYP1A2 (0.82) CYP1A2KDM4EMEN1CYP2D6CYP2C19
SCHEMBL8784512 0.87 CYP1A2 (0.77) CYP1A2KDM4EMEN1CYP2D6CYP2C19
SCHEMBL8784112 0.87 CYP1A2 (0.77) CYP1A2KDM4EMEN1CYP2D6CYP2C19
SCHEMBL8784076 0.87 CYP1A2 (0.77) CYP1A2KDM4EMEN1CYP2D6CYP2C19
SCHEMBL8783533 0.87 CYP1A2 (0.77) CYP1A2KDM4EMEN1CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4629989-A2 TREATMENT OR PREVENTION OF DEPRESSIVE DISORDERS THROUGH COMBINATION THERAPY Freedom Biosciences, Inc. (US) 2025-10-15 EP claimed
US-20240350433-A1 TREATMENT COMPOSITIONS AND METHODS UNIV YALE (US) 2024-10-24 US claimed
WO-2024123935-A2 TREATMENT OR PREVENTION OF DEPRESSIVE DISORDERS THROUGH COMBINATION THERAPY FREEDOM BIOSCIENCES, INC. (US) 2024-06-13 WO claimed
US-20250375421-A1 METHODS OF USING DMT SHULMAN WILLIAM (US) 2025-12-11 US disclosed
EP-4633638-A1 TREATMENT OF PSYCHOLOGICAL FACTORS AFFECTING OTHER MEDICAL CONDITIONS (PFAOMC) Luminous Mind Inc. (US) 2025-10-22 EP disclosed
EP-4629989-A2 TREATMENT OR PREVENTION OF DEPRESSIVE DISORDERS THROUGH COMBINATION THERAPY Freedom Biosciences, Inc. (US) 2025-10-15 EP disclosed
US-20250312353-A1 DRUG REPURPOSING FOR TREATMENT OF CONGENITAL VASCULAR MALFORMATIONS UNIVERSITY OF SOUTH CAROLINA (US) 2025-10-09 US disclosed
US-12396981-B2 Methods of using DMT SHULMAN WILLIAM (US) 2025-08-26 US disclosed
EP-4580679-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND NMDA RECEPTOR ANTAGONISTS Biohaven Therapeutics Ltd. (VG) 2025-07-09 EP disclosed
US-20250163130-A1 LIGAND GATED ION CHANNELS AND METHODS OF USE SWITCH BIO, INC. 2025-05-22 US disclosed
US-20250152742-A1 COMPOSITIONS AND METHODS FOR NEUROLOGICAL DISEASES TRAMES BIO, INC. 2025-05-15 US disclosed
US-20220348635-A1 COMPOSITIONS AND METHODS FOR NEUROLOGICAL DISEASES TRAMES BIO, INC. 2022-11-03 US disclosed
US-20220244263-A1 METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-08-04 US disclosed
CN-114728012-A Ganaxolone for the treatment of status epilepticus 马瑞纳斯制药公司 2022-07-08 CN disclosed
EP-3116509-B1 A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS UNIV COLUMBIA (US) 2022-06-22 EP disclosed
US-20220135564-A1 DEUTERATED MITRAGYNINE ANALOGS AS SAFER OPIOID MODULATORS IN THE MITRAGYNINE CLASS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2022-05-05 US disclosed
WO-2022074588-A1 CARBOXYLIC DIARYLTHIAZEPINEAMINES AND USES THEREFOR KURES, INC. (US) 2022-04-14 WO disclosed
WO-2022074589-A1 CARBOXYLIC DIARYLTHIAZEPINEAMINES AND USES THEREFOR KURES, INC. (US) 2022-04-14 WO disclosed
WO-2022074587-A1 MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR KURES, INC. (US) 2022-04-14 WO disclosed
US-20220106279-A1 CLASS OF MU-OPIOID RECEPTOR AGONISTS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2022-04-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12396981-B2 Methods of using DMT PNMT, HTR6, HTR1A CYP1A2 1738/4885KDM4E 110/4885MEN1 1347/4885
US-20220106279-A1 CLASS OF MU-OPIOID RECEPTOR AGONISTS OPRM1, OPRL1, OPRK1 CYP1A2 748/4885KDM4E 2011/4885MEN1 4601/4885
US-20250375421-A1 METHODS OF USING DMT PNMT, HTR6, HTR1A CYP1A2 1738/4885KDM4E 110/4885MEN1 1347/4885
US-20250152742-A1 COMPOSITIONS AND METHODS FOR NEUROLOGICAL DISEASES CHRNB2, CHRNA2, CHRNA6 CYP1A2 4875/4885KDM4E 4711/4885MEN1 2410/4885
US-20250163130-A1 LIGAND GATED ION CHANNELS AND METHODS OF USE CACNB2, CHRNA2, HCN3 CYP1A2 4866/4885KDM4E 4673/4885MEN1 3711/4885
US-20220135564-A1 DEUTERATED MITRAGYNINE ANALOGS AS SAFER OPIOID MODULATORS IN THE MITRAGYNINE CLASS OPRD1, OPRK1, OPRM1 CYP1A2 745/4885KDM4E 910/4885MEN1 3100/4885
US-20220348635-A1 COMPOSITIONS AND METHODS FOR NEUROLOGICAL DISEASES CHRNB2, CHRNA2, CHRNA6 CYP1A2 4875/4885KDM4E 4711/4885MEN1 2410/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.