Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | CLK1 | P49759 | 7/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL447565 | 0.91 | HDAC1 (0.49) | HDAC1CLK1CLK2RAB9ANPC1 | |
| SCHEMBL4249835 | 0.88 | CLK1 (0.58) | HDAC1CLK1CLK2NPC1DYRK1A | |
| SCHEMBL4255195 | 0.88 | NPC1 (0.51) | HDAC1CLK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL4252262 | 0.87 | HDAC1 (0.52) | HDAC1CLK1RAB9ANPC1MEN1 | |
| SCHEMBL4252178 | 0.85 | NPC1 (0.47) | HDAC1CLK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL4251113 | 0.84 | RAB9A (0.57) | HDAC1CLK1RAB9AMEN1KMT2A | |
| SCHEMBL4249825 | 0.82 | HDAC1 (0.48) | HDAC1CLK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL4257504 | 0.79 | HDAC1 (0.47) | HDAC1CLK1RAB9ANPC1POLB | |
| SCHEMBL4253856 | 0.79 | MEN1 (0.50) | RAB9ANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL445756 | 0.78 | CLK1 (0.61) | HDAC1CLK1CLK2NPC1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | HDAC1 1/4885CLK1 3179/4885CLK2 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.