Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | KCNA6 | P17658 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.46 |
| ▸ | KCNA4 | P22459 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446978 | 0.91 | HDAC1 (0.58) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4250970 | 0.88 | KDM4E (0.61) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4251122 | 0.87 | KDM4E (0.55) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4249821 | 0.83 | HDAC1 (0.47) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4253856 | 0.79 | MEN1 (0.50) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL444819 | 0.78 | KDM4E (0.64) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4253298 | 0.78 | HDAC1 (0.45) | HDAC1HDAC2HDAC6ALDH1A1 | |
| SCHEMBL4253730 | 0.78 | HDAC3 (0.59) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL446419 | 0.77 | KDM4E (0.56) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4254285 | 0.75 | NPC1 (0.48) | HDAC1HDAC2HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | HDAC1 1/4885HDAC2 4/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.