Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246994 | 0.85 | ALDH1A1 (0.47) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL1666306 | 0.85 | ALDH1A1 (0.74) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL3004313 | 0.80 | ALDH1A1 (0.56) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL3248414 | 0.77 | MAPT (0.57) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL10849548 | 0.77 | KDM4E (0.55) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL7384754 | 0.76 | ALDH1A1 (0.62) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL7379493 | 0.76 | ALDH1A1 (0.65) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL10789635 | 0.75 | KDM4E (0.58) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL11752901 | 0.75 | ALDH1A1 (1.00) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL27692194 | 0.74 | KDM4E (0.52) | ALDH1A1MAPTKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |