Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 10/20 | 0.79 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3228262 | 0.93 | NR3C1 (0.80) | NR3C1PGRCDK8ROCK1FLT1 | |
| SCHEMBL3227200 | 0.91 | NR3C1 (0.77) | NR3C1PGRCDK8ROCK1FLT1 | |
| SCHEMBL3235149 | 0.89 | NR3C1 (0.74) | NR3C1PGRCDK8ROCK1FLT1 | |
| SCHEMBL3232751 | 0.89 | NR3C1 (0.73) | NR3C1PGRCDK8ROCK1FLT1 | |
| SCHEMBL3234751 | 0.89 | NR3C1 (0.76) | NR3C1PGRCDK8ROCK1FLT1 | |
| SCHEMBL3222388 | 0.89 | NR3C1 (0.73) | NR3C1PGRCDK8ROCK1FLT1 | |
| SCHEMBL3232747 | 0.89 | NR3C1 (0.73) | NR3C1PGRCDK8ROCK1FLT1 | |
| SCHEMBL3234015 | 0.89 | NR3C1 (0.73) | NR3C1PGRCDK8ROCK1FLT1 | |
| SCHEMBL3228486 | 0.89 | NR3C1 (1.00) | NR3C1PGRCDK8ROCK1FLT1 | |
| SCHEMBL3231046 | 0.88 | NR3C1 (0.75) | NR3C1PGRCDK8ROCK1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116538-B1 | CONDENSED TETRAHYDROQUINOLINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-03-27 | — | — | EP | disclosed |
| EP-2116538-A1 | CONDENSED TETRAHYDROQUINOLINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | Mitsubishi Tanabe Pharma Corporation (JP) | 2009-11-11 | — | — | EP | disclosed |