Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 5/20 | 0.47 |
| ▸ | TPO | P07202 | 3/20 | 0.47 |
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.40 |
| ▸ | IL6 | P05231 | 9/20 | 0.38 |
| ▸ | GRN | P28799 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2284086 | 0.86 | MPO (0.61) | MPOTPOPNPTLR7IL6 | |
| SCHEMBL31025270 | 0.86 | MPO (0.61) | MPOTPOPNPTLR7IL6 | |
| SCHEMBL4251233 | 0.78 | MPO (0.48) | MPOTPOPNPCYP3A4KCNH2 | |
| SCHEMBL4248896 | 0.77 | MPO (0.43) | MPOTPOPNPCYP3A4KCNH2 | |
| SCHEMBL4246904 | 0.74 | MPO (0.42) | MPOTPOPNPCYP3A4KCNH2 | |
| SCHEMBL1461239 | 0.68 | MPO (0.74) | MPOTPOPNPTLR7CYP3A4 | |
| SCHEMBL2278851 | 0.67 | MPO (0.67) | MPOTPOPNPTLR7CYP3A4 | |
| SCHEMBL31025321 | 0.67 | MPO (0.67) | MPOTPOPNPTLR7CYP3A4 | |
| SCHEMBL1460860 | 0.66 | MPO (1.00) | MPOTPOPNPCYP3A4KCNH2 | |
| SCHEMBL2286250 | 0.64 | MPO (0.77) | MPOTPOPNPCYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010535-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120098-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |