Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | CASP1 | P29466 | 4/20 | 0.51 |
| ▸ | CASP7 | P55210 | 4/20 | 0.51 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249005 | 0.92 | LMNA (0.72) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3245063 | 0.91 | SMN1; SMN2 (0.73) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3326457 | 0.87 | LMNA (0.66) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2992233 | 0.86 | SMN1; SMN2 (0.77) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3325556 | 0.85 | LMNA (0.68) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2848300 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2848302 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2849024 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2846778 | 0.82 | HSD17B10 (0.59) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2846776 | 0.82 | HSD17B10 (0.59) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |