Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | P2RY12 | Q9H244 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258468 | 0.93 | MAPT (0.46) | BRD4KMT2AP2RY12MAPTL3MBTL1 | |
| SCHEMBL444210 | 0.91 | KMT2A (0.52) | BRD4KMT2AALOX15P2RY12MAPT | |
| SCHEMBL4254095 | 0.88 | MAPT (0.46) | P2RY12MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL4258464 | 0.87 | MAPT (0.49) | KMT2AMAPTL3MBTL1NPC1RECQL | |
| SCHEMBL4254741 | 0.87 | MAPT (0.44) | BRD4KMT2AP2RY12MAPTL3MBTL1 | |
| SCHEMBL445440 | 0.86 | ALOX15 (0.49) | BRD4KMT2AALOX15P2RY12 | |
| SCHEMBL443046 | 0.84 | MAPT (0.48) | BRD4KMT2AP2RY12MAPTL3MBTL1 | |
| SCHEMBL4255700 | 0.83 | P2RY12 (0.47) | ALOX15P2RY12 | |
| SCHEMBL4251739 | 0.83 | ALOX15 (0.48) | ALOX15P2RY12MAPT | |
| SCHEMBL4251195 | 0.82 | P2RY12 (0.49) | ALOX15P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | BRD4 47/4885KMT2A 94/4885ALOX15 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.